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KMID : 1023420150150020098
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Journal of Dental Hygiene Science
2015 Volume.15 No. 2 p.98 ~ p.105
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Effect of Mutan Isolated from Streptococcus mutans on the Healing of Bone Defect in Rat
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Kwon Hyun-Jung
Kim Yong-Hyun
Han Kook-Il
Jung Eui-Gil
Han Man-Deuk
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Abstract
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We investigated the effects of a mutan (water-insoluble a-glucans) isolated from Streptococcus mutans on the healing of bone defect in rat. Sprague-Dawley rats were divided into control (saline-treated), lipopolysaccharide (LPS)-treated, and mutan-treated groups (n=6 per group). Experimental bone defects were surgically created with round fissure bur at the buccal surface of the left mandibular. The control groups was administered with saline solution (0.1 ml/100 g), while the LPS and mutan group was given LPS and mutan (1 mg/kg body weight) three times weekly. After 4 weeks the rats were sacrificed, the healing of bone defect was assessed by bone mineral density (BMD) and micro-computed tomography (mCT) examination. Percent bone volume (bone volume/tissue volume [BV/TV]), trabecular thickness (Tb.Th), and trabecular number (Tb.N) parameters of mCT showed higher values in control group than LPS and mutan group. Bone surface/volume ratio (BS/BV), trabecular bone pattern factor (Tb.Pf), and structure model index parameters of mCT showed higher values in LPS group than mutan group. BMD values of mutan treated-alveolar bones were significantly lower for than that of the LPS group. Therefore, we suggest that mutan, water-insoluble a-glucans from S. mutans may be induce the induction of periodontal diseases.
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KEYWORD
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Bone defect , Micro-computed tomography , Mutan , Streptococcus mutans , a-1, 3-glucan
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